|Other Names||Signal transducer and activator of transcription 6, IL-4 Stat, STAT6|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3270a was selected from the region of human Phospho-STAT6-Y641. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation|
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Provided below are standard protocols that you may find useful for product applications.
STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.
Valineva, T., et al., J. Biol. Chem. 280(15):14989-14996 (2005).Tang, X., et al., Proc. Natl. Acad. Sci. U.S.A. 102(14):5132-5137 (2005).Heller, N.M., et al., Am. J. Respir. Cell Mol. Biol. 31(5):573-582 (2004).Galka, E., et al., J. Surg. Res. 122(1):14-20 (2004).Zhang, W.J., et al., Int. J. Oncol. 24(2):447-453 (2004).
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