|Other Names||Non-receptor tyrosine-protein kinase TYK2, TYK2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3283a was selected from the region of human Phospho-TyK2-Y1054/1055. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.|
|Tissue Location||Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines|
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Provided below are standard protocols that you may find useful for product applications.
TYK2 is likely involved in intracellular signal transduction via involvement in the initiation of type I IFN signaling. TYK2 Phosphorylates the interferon-alpha/beta receptor alpha chain. In animal models TYK2 is an important regulator of lymphoid tumor surveillance.
Lukashova, V., et al., J. Immunol. 171(7):3794-3800 (2003).Kiian, I., et al., Thromb. Haemost. 89(5):904-914 (2003).Ragimbeau, J., et al., EMBO J. 22(3):537-547 (2003).Trask, B., et al., Genomics 15(1):133-145 (1993).Firmbach-Kraft, I., et al., Oncogene 5(9):1329-1336 (1990).
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