Phospho-NR4A1-S351 Antibody Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Other Accession | Q9Z239 |
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Clone Names | 110172 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP3288a was selected from the region of human Phospho-NR4A1-S351. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
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Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
NR4A1 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis.
References
Lu, L., et al., J. Clin. Endocrinol. Metab. 89(8):4113-4118 (2004).Castro-Obregon, S., et al., J. Biol. Chem. 279(17):17543-17553 (2004).Lin, B., et al., Cell 116(4):527-540 (2004).Choi, J.W., et al., Cancer Res. 64(1):35-39 (2004).Ye, X., et al., Int. J. Biochem. Cell Biol. 36(1):98-113 (2004).
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