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Phospho-JUN(T239) Antibody Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P05412
Clone Names 110082
Additional Information
Gene ID 3725
Other Names Transcription factor AP-1, Activator protein 1, AP1, Proto-oncogene c-Jun, V-jun avian sarcoma virus 17 oncogene homolog, p39, JUN
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3292a was selected from the region of human Phospho-JUN-T239. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name JUN
Function Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
Cellular Location Nucleus.
Tissue Location Expressed in the developing and adult prostate and prostate cancer cells.
Research Areas
Citations (0)
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Background

This gene for the cJun protein is the putative transforming gene of avian sarcoma virus 17. The protein is highly similar to the viral protein, and interacts directly with specific target DNA sequences to regulate gene expression. The gene for this protein is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.

References

Fang, D., et al., Proc. Natl. Acad. Sci. U.S.A. 101(41):14782-14787 (2004).Wang, Y., et al., Biochem. Biophys. Res. Commun. 323(1):9-16 (2004).Wehkamp, J., et al., Infect. Immun. 72(10):5750-5758 (2004).Gensch, E., et al., J. Biol. Chem. 279(37):39085-39093 (2004).Fujioka, S., et al., Mol. Cell. Biol. 24(17):7806-7819 (2004).

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$ 277.78
Cat# BP3292a
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Availability: 2 weeks
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