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Phospho-Gab1(Y659) Antibody Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13480 |
|---|---|
| Clone Names | 6101869 |
| Gene ID | 2549 |
|---|---|
| Other Names | GRB2-associated-binding protein 1, GRB2-associated binder 1, Growth factor receptor bound protein 2-associated protein 1, GAB1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP3302b was selected from the region of human Phospho-Gab1-Y659. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GAB1 |
|---|---|
| Function | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Gab1 is a member of the IRS1-like multisubstrate docking protein family. This protein is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis.
References
Podar, K., et al., J. Biol. Chem. 279(20):21658-21665 (2004).Ren, Y., et al., J. Biol. Chem. 279(9):8497-8505 (2004).Kapoor, G.S., et al., Mol. Cell. Biol. 24(2):823-836 (2004).Nakaoka, Y., et al., Circ. Res. 93(3):221-229 (2003).Holgado-Madruga, M., et al., Mol. Cell. Biol. 23(13):4471-4484 (2003).
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