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Phospho-HSPA1A(Y525) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession P08107
Clone Names 110071
Peptide ID 110071
Additional Information
Gene ID 3303;3304
Other Names Heat shock 70 kDa protein 1A/1B, Heat shock 70 kDa protein 1/2, HSP70-1/HSP70-2, HSP701/HSP702, HSPA1A, HSPA1, HSX70
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3316a was selected from the region of human Phospho-HSPA1A-Y525. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HSPA1, HSX70
Function In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).
Cellular Location Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
Tissue Location HSPA1B is testis-specific.
Research Areas
Citations (0)

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HSPA1A is a member of the heat shock protein 70 family. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene for this protein is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.


Mueller, T., et al., Transplantation 78(2):292-295 (2004).Fekete, A., et al., Pediatr. Res. 54(4):452-455 (2003).Broquet, A.H., et al., J. Biol. Chem. 278(24):21601-21606 (2003).Bruce, C.R., et al., Diabetes 52(9):2338-2345 (2003).Anwar, A., et al., J. Biol. Chem. 277(16):14060-14067 (2002).

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$ 80.00
Cat# BP3316a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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