|Other Names||Neurofibromin, Neurofibromatosis-related protein NF-1, Neurofibromin truncated, NF1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3327a was selected from the region of human Phospho-NF1-S2515. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.|
|Cellular Location||Nucleus. Nucleus, nucleolus|
|Tissue Location||Detected in brain, peripheral nerve, lung, colon and muscle.|
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NF1 encodes the protein neurofibromin, which appears to be a negative regulator of the ras signal transduction pathway. Mutations linked to neurofibromatosis type 1 led to the identification of NF1. In addition to type 1 neurofibromatosis, mutations in NF1 can also lead to juvenile myelomonocytic leukemia.
Zhu, C., et al., J. Biol. Chem. 279(49):50874-50885 (2004).Zou, M.X., et al., Oncogene 23(2):330-339 (2004).Lasota, J., et al., Lab. Invest. 83(9):1361-1371 (2003).Baralle, D., et al., BMC Dermatol. 119(1):1-8 (2003).Wang, Q., et al., Hum. Genet. 112(2):117-123 (2003).
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