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Phospho-NF1(S2515) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession P21359
Clone Names 110159
Peptide ID 110159
Additional Information
Gene ID 4763
Other Names Neurofibromin, Neurofibromatosis-related protein NF-1, Neurofibromin truncated, NF1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3327a was selected from the region of human Phospho-NF1-S2515. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NF1
Function Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.
Cellular Location Nucleus. Nucleus, nucleolus
Tissue Location Detected in brain, peripheral nerve, lung, colon and muscle.
Research Areas
Citations (0)

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NF1 encodes the protein neurofibromin, which appears to be a negative regulator of the ras signal transduction pathway. Mutations linked to neurofibromatosis type 1 led to the identification of NF1. In addition to type 1 neurofibromatosis, mutations in NF1 can also lead to juvenile myelomonocytic leukemia.


Zhu, C., et al., J. Biol. Chem. 279(49):50874-50885 (2004).Zou, M.X., et al., Oncogene 23(2):330-339 (2004).Lasota, J., et al., Lab. Invest. 83(9):1361-1371 (2003).Baralle, D., et al., BMC Dermatol. 119(1):1-8 (2003).Wang, Q., et al., Hum. Genet. 112(2):117-123 (2003).

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$ 120.00
Cat# BP3327a
Availability: In Stock
Bulk Size
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