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Phospho-EIF4EBP1-pT69 Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q13541
Other Accession Q0P5A7
Additional Information
Gene ID 1978
Other Names Eukaryotic translation initiation factor 4E-binding protein 1, 4E-BP1, eIF4E-binding protein 1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, PHAS-I, EIF4EBP1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Research Areas
Citations (0)

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This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.


Peffley,D.M., Arch. Biochem. Biophys. 465 (1), 266-273 (2007) Fonseca,B.D., J. Biol. Chem. 282 (34), 24514-24524 (2007) Armengol,G., Cancer Res. 67 (16), 7551-7555 (2007) Rojo,F., Clin. Cancer Res. 13 (1), 81-89 (2007)

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$ 80.00
Cat# BP3362a
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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