Phospho-ELK1(S389) Antibody Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P19419 |
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Clone Names | 110052 |
Gene ID | 2002 |
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Other Names | ETS domain-containing protein Elk-1, ELK1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP3377a was selected from the region of human Phospho-ELK1-S389. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ELK1 |
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Function | Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK- signaling pathway stimulation (By similarity). |
Cellular Location | Nucleus. |
Tissue Location | Lung and testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ELK1 is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein is a nuclear target for the ras-raf-MAPK signaling cascade.
References
Salinas, S., et al., J. Cell Biol. 165(6):767-773 (2004).Yang, S.H., et al., Mol. Cell 12(1):63-74 (2003).Bebien, M., et al., Oncogene 22(12):1836-1847 (2003).Sharrocks, A.D., Biochem. Soc. Trans. 30(2):1-9 (2002).Murai, K., et al., Mol. Cell. Biol. 22(20):7083-7092 (2002).
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