|Other Names||Myocyte-specific enhancer factor 2C, MEF2C|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3385a was selected from the region of human Phospho-MEF2C-pS387. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.|
|Tissue Location||Expressed in brain and skeletal muscle.|
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MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. This protein controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. It may also be involved in neurogenesis and in the development of cortical architecture.
Konig, S., et al., J. Biol. Chem. 279(27):28187-28196 (2004).Maeda, T., et al., J. Biol. Chem. 277(50):48889-48898 (2002).Maeda, T., et al., Biochem. Biophys. Res. Commun. 294(4):791-797 (2002).Janson, C.G., et al., Brain Res. Mol. Brain Res. 97(1):70-82 (2001).Krainc, D., et al., Genomics 29(3):809-811 (1995).
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