|Other Names||Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription factor p64, MYC, BHLHE39|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3386a was selected from the region of human Phospho-MYC-T358. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'- CAC[GA]TG-3'. Activates the transcription of growth-related genes.|
|Cellular Location||Nucleus, nucleoplasm. Nucleus, nucleolus|
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Provided below are standard protocols that you may find useful for product applications.
MYC participates in the regulation of gene transcription. It binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. This protein appears to activate the transcription of growth-related genes. Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia.
Qi, Y., et al., Nature 431(7009):712-717 (2004).Wilda, M., et al., Genes Chromosomes Cancer 41(2):178-182 (2004).Dom, et al., Oncogene 23(44):7378-7390 (2004).Pap, T., et al., Arthritis Rheum. 50(9):2794-2802 (2004).Ozawa, N., et al., Endocrinology 145(9):4244-4250 (2004).
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