|Other Names||Ras-related protein Rab-24, RAB24|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3393a was selected from the region of human Phospho-RAB24-Y17. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in autophagy-related processes.|
|Cellular Location||Cytoplasm, cytosol. Membrane; Lipid-anchor Note=Only about 20-25% is recovered in the particulate fraction|
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Provided below are standard protocols that you may find useful for product applications.
Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The GTPase Rab24 is thought to be involved in the regulation of vesicular transport associated with autophagy.
Maltese,W.A., BMC Cell Biol. 3, 25 (2002)Erdman,R.A., J. Biol. Chem. 275 (6), 3848-3856 (2000)Olkkonen,V.M., J. Cell. Sci. 106 (PT 4), 1249-1261 (1993)
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