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Phospho-RGS19(S151) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession P49795
Clone Names 70226205
Peptide ID 70226205
Additional Information
Gene ID 10287
Other Names Regulator of G-protein signaling 19, RGS19, G-alpha-interacting protein, GAIP, RGS19, GAIP, GNAI3IP
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3397a was selected from the region of human Phospho-RGS19-S151. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RGS19
Synonyms GAIP, GNAI3IP
Function Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
Cellular Location Membrane; Lipid-anchor.
Tissue Location Highest expression in lung. Placenta, liver and heart also express high levels of GAIP
Research Areas
Citations (0)

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Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). RGS19 enhances the intrinsic GTPase-activating protein activity of the Galphai3 protein, which stimulates autophagy by favoring the GDP-bound form of Galphai3.


Baehrecke EH. Nat Rev Mol Cell Biol. 6(6):505-10. (2005) Lum JJ, et al. Nat Rev Mol Cell Biol. 6(6):439-48. (2005) Greenberg JT. Dev Cell. 8(6):799-801. (2005) Levine B. Cell. 120(2):159-62. (2005) Shintani T and Klionsky DJ. Science. 306(5698):990-5. (2004)de Vries L., et al. PNAS 93:15203-15208(1996) de Alba E., et al. J. Mol. Biol. 291:927-939(1999) Wang J., et al. J. Biol. Chem. 273:26014-26025(1998) Ogier-Denis E., et al. J. Biol. Chem. 275:39090-39095(2000)

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$ 80.00
Cat# BP3397a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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