|Other Names||Tyrosine-protein phosphatase non-receptor type 7, Hematopoietic protein-tyrosine phosphatase, HEPTP, Protein-tyrosine phosphatase LC-PTP, PTPN7|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3404a was selected from the region of human Phospho-PTPN7-S246. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton|
|Tissue Location||Expressed exclusively in thymus and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
PTPN7 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN7 is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP has been shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which is thought to function through dephosphorylating the molecules related to MAP kinase pathway.
Eswaran,J., Biochem. J. 395 (3), 483-491 (2006)Mustelin,T., J. Mol. Biol. 354 (1), 150-163 (2005)Pettiford,S.M., Leukemia 17 (2), 366-378 (2003)Kosaki,K., J. Clin. Endocrinol. Metab. 87 (8), 3529-3533 (2002)
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