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Phospho-PTPN7(S246) Antibody Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P35236
Clone Names 110192
Additional Information
Gene ID 5778
Other Names Tyrosine-protein phosphatase non-receptor type 7, Hematopoietic protein-tyrosine phosphatase, HEPTP, Protein-tyrosine phosphatase LC-PTP, PTPN7
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3404a was selected from the region of human Phospho-PTPN7-S246. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTPN7
Function Protein phosphatase that acts preferentially on tyrosine- phosphorylated MAPK1. Plays a role in the regulation of T and B- lymphocyte development and signal transduction.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton
Tissue Location Expressed exclusively in thymus and spleen.
Research Areas
Citations (0)
citation

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Background

PTPN7 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN7 is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP has been shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which is thought to function through dephosphorylating the molecules related to MAP kinase pathway.

References

Eswaran,J., Biochem. J. 395 (3), 483-491 (2006)Mustelin,T., J. Mol. Biol. 354 (1), 150-163 (2005)Pettiford,S.M., Leukemia 17 (2), 366-378 (2003)Kosaki,K., J. Clin. Endocrinol. Metab. 87 (8), 3529-3533 (2002)

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$ 277.78
Cat# BP3404a
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Availability: 2 weeks
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