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Phospho-NFATC2-pS330 Antibody Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP3429a | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
Phospho-NFATC2-pS330 Antibody Blocking Peptide - Product info | |
| Primary Accession | Q13469 |
| Other Accession | NP_036472 |
| Clone Names | 110162 |
| Calculated MW | 100146 Da |
Phospho-NFATC2-pS330 Antibody Blocking Peptide - Additional info | |
| Gene ID 4773 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP3429a was selected from the region of human Phospho-NFATC2-pS330. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
Phospho-NFATC2-pS330 Antibody Blocking Peptide - Protein Information | |
| Name NFATC2 | |
| Synonyms NFAT1, NFATP | |
| Function Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway | |
| Cellular Location Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals The subcellular localization of NFATC plays a key role in the regulation of gene transcription | |
| Tissue Location Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas. Isoform 1 is highly expressed in the small intestine, heart, testis, prostate, thymus, placenta and thyroid. Isoform 3 is highly expressed in stomach, uterus, placenta, trachea and thyroid | |
Phospho-NFATC2-pS330 Antibody Blocking Peptide - Related products
AP3429a: Phospho-NFATC2-pS330 Antibody
AP3508a: Phospho-NFATC2-pS326 Antibody
AP7766a: NFATC2 Antibody (S330)
RI13570: NFATC2 predesign siRNA
BP3429a: Phospho-NFATC2-pS330 Antibody Blocking Peptide
BP3508a: Phospho-NFATC2-pS326 Antibody Blocking Peptide
Phospho-NFATC2-pS330 Antibody Blocking Peptide - Research Areas
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BACKGROUND
NFATC2 is a member of the nuclear factor of activated T cells (NFAT) family. It is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response.
REFERENCES
Golks,A., EMBO J. 26 (20), 4368-4379 (2007)Dong,X., J. Biol. Chem. 282 (41), 30303-30310 (2007)Gibson,H.M., J. Immunol. 179 (6), 3831-3840 (2007)
