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Phospho-TSC2(S1420) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession P49815
Clone Names 110254
Peptide ID 110254
Additional Information
Gene ID 7249
Other Names Tuberin, Tuberous sclerosis 2 protein, TSC2, TSC4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3480a was selected from the region of human Phospho-TSC2-S1420. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TSC2
Synonyms TSC4
Function In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase- activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes
Tissue Location Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta
Research Areas
Citations (0)

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Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.


Li, Y., et al., Mol. Cell. Biol. 24(18):7965-7975 (2004).Karbowniczek, M., et al., J. Biol. Chem. 279(29):29930-29937 (2004).Corradetti, M.N., et al., Genes Dev. 18(13):1533-1538 (2004).Birchenall-Roberts, M.C., et al., J. Biol. Chem. 279(24):25605-25613 (2004).Lewis, J.C., et al., J. Med. Genet. 41(3):203-207 (2004).

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$ 80.00
Cat# BP3480a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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