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Phospho-ILK(S246) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q13418
Other Accession NP_004508
Clone Names 70903111
Peptide ID 70903111
Additional Information
Gene ID 3611
Other Names Integrin-linked protein kinase, 59 kDa serine/threonine-protein kinase, ILK-1, ILK-2, p59ILK, ILK, ILK1, ILK2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3514a was selected from the region of human Phospho-ILK-pS246. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ILK
Synonyms ILK1, ILK2
Function Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Cellular Location Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere
Tissue Location Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver
Research Areas
Citations (0)

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Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. ILK is a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction.


Li, Y., et al., J. Clin. Invest. 112(4):503-516 (2003).Troussard, A.A., et al., J. Biol. Chem. 278(25):22374-22378 (2003).Marotta, A., et al., Br. J. Cancer 88(11):1755-1762 (2003).Cordes, N., et al., Br. J. Cancer 88(9):1470-1479 (2003).Fukuda, T., et al., J. Cell Biol. 160(7):1001-1008 (2003).

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$ 80.00
Cat# BP3514a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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