|Other Names||Glial fibrillary acidic protein, GFAP, GFAP|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3562a was selected from the region of human Phospho-GFAP-pS8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.|
|Cellular Location||Cytoplasm. Note=Associated with intermediate filaments|
|Tissue Location||Expressed in cells lacking fibronectin.|
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Provided below are standard protocols that you may find useful for product applications.
GFAP is one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system.
Quintanar, J.L., et al., Parasitol. Res. 90(4):261-263 (2003).Shiroma, N., et al., Brain Dev. 25(2):116-121 (2003).Nielsen, A.L., et al., J. Biol. Chem. 277(33):29983-29991 (2002).Namekawa, M., et al., Ann. Neurol. 52(6):779-785 (2002).Lopez-Egido, J., et al., Exp. Cell Res. 278(2):175-183 (2002).
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