|Other Names||Microtubule-associated protein 2, MAP-2, MAP2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3591a was selected from the region of human Phospho-MAP2-pY592. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.|
|Cellular Location||Cytoplasm, cytoskeleton.|
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
MAP2 is a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The exact function of this protein is still unknown. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development.
Lauckner, J., et al., Neurobiol. Aging 24(6):767-776 (2003).Laurine, E., et al., J. Biol. Chem. 278(32):29979-29986 (2003).Liu, Y., et al., Adv Anat Pathol 10(2):101-106 (2003).DeTure, M.A., et al., J. Biol. Chem. 277(38):34755-34759 (2002).Al-Bassam, J., et al., J. Cell Biol. 157(7):1187-1196 (2002).
If you have any additional inquiries please email technical services at firstname.lastname@example.org.