|Other Names||Insulin receptor substrate 2, IRS-2, IRS2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3596a was selected from the region of human Phospho-IRS2-pY978. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May mediate the control of various cellular processes by insulin.|
|Cellular Location||Cytoplasm, cytosol.|
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Provided below are standard protocols that you may find useful for product applications.
Insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. This protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
Hagg,D.A., Int. J. Mol. Med. 21 (6), 697-704 (2008)Platanias,L.C., J. Biol. Chem. 271 (1), 278-282 (1996)Sun,X.J., Nature 377 (6545), 173-177 (1995)
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