|Other Names||Insulin receptor substrate 1, IRS-1, IRS1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3625a was selected from the region of human Phospho-IRS1-pY1179. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
IRS1 may mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor it binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. It activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
Kawakami,A., Circulation 118 (7), 731-742 (2008)Yi,Z., Anal. Chem. 77 (17), 5693-5699 (2005)
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