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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Phospho-FALZ(S77) Antibody Blocking peptide   

Phospho-FALZ(S77) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q12830
Clone Names 80130193
Peptide ID 80130193
Additional Information
Gene ID 2186
Other Names Nucleosome-remodeling factor subunit BPTF, Bromodomain and PHD finger-containing transcription factor, Fetal Alz-50 clone 1 protein, Fetal Alzheimer antigen, BPTF, FAC1, FALZ
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3629a was selected from the region of human Phospho-FALZ-pS77. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FAC1, FALZ
Function Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
Cellular Location Cytoplasm. Nucleus. Note=In brains of Alzheimer disease patients, present in a subset of amyloid- containing plaques
Tissue Location Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level)
Research Areas
Citations (0)

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Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription.


Grinberg-Rashi,H., Clin. Cancer Res. 15 (5), 1755-1761 (2009)Olsen,J.V., Cell 127 (3), 635-648 (2006

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$ 80.00
Cat# BP3629a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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Ordering Information

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