|Other Names||Protein S100-A11, Calgizzarin, Metastatic lymph node gene 70 protein, MLN 70, Protein S100-C, S100 calcium-binding protein A11, Protein S100-A11, N-terminally processed, S100A11, MLN70, S100C|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3630a was selected from the region of human Phospho-S100A11-pS6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Facilitates the differentiation and the cornification of keratinocytes.|
|Cellular Location||Cytoplasm. Nucleus|
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Protein S100-A11 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.
Howell,M.D., J. Invest. Dermatol. 128 (9), 2248-2258 (2008)Cecil,D.L., J. Immunol. 180 (12), 8378-8385 (2008)Sakaguchi,M., J. Cell Biol. 163 (4), 825-835 (2003)
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