|Other Names||Claudin-2, SP82, CLDN2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3639a was selected from the region of human Phospho-CLDN2-pY224. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions.
Morita,K., Proc. Natl. Acad. Sci. U.S.A. 96 (2), 511-516 (1999)Furuse,M., J. Cell Biol. 141 (7), 1539-1550 (1998)
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