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Phospho-CLDN2(Y224) Antibody Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P57739 |
|---|---|
| Other Accession | NP_065117 |
| Clone Names | 80130179 |
| Gene ID | 9075 |
|---|---|
| Other Names | Claudin-2, SP82, CLDN2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP3639a was selected from the region of human Phospho-CLDN2-pY224. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CLDN2 |
|---|---|
| Function | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. |
| Cellular Location | Cell junction, tight junction {ECO:0000250|UniProtKB:O88552}. Cell membrane {ECO:0000250|UniProtKB:O88552}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O88552} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions.
References
Morita,K., Proc. Natl. Acad. Sci. U.S.A. 96 (2), 511-516 (1999)Furuse,M., J. Cell Biol. 141 (7), 1539-1550 (1998)
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