|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3661a was selected from the M region of human Phospho-ErbB2-pY1248(M). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
ErbB2 is a member of the epidermal growth factor(EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a(positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here.
Wang,S.E., et.al., Cancer Cell 10 (1), 25-38 (2006)Dankort,D., et.al., J. Biol. Chem. 276 (42), 38921-38928 (2001)Gulliford,T., et.al., Cell. Signal. 11 (4), 245-252 (1999)
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