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Phospho-LINGO-1(LRRN6A)(S596) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9D1T0
Clone Names 80130231
Peptide ID 80130231
Additional Information
Gene ID 235402
Other Names Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A, Lingo1, Lern1, Lrrn6a
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3685a was selected from the LRRN6A-pS596 region of human Phospho-LINGO-1(LRRN6A)-pS596. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Lingo1
Synonyms Lern1, Lrrn6a
Function Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Highly specific expression in the central nervous system. Predominant expression in neocortex, amygdala, hippocampus, thalamus and entorhinal cortex, with lower levels in cerebellum and basal nuclei.
Research Areas
Citations (0)

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LINGO-1 (LRR and Ig domain-containing Nogo Receptor interating protein) is a nervous system-specific LRR-Ig-containing protein with an important role in CNS biology. LINGO-1 was discovered in a sequence database search for human SLIT homologs that were selectively expressed in the brain. LINGO-1 is a transmembrane protein that is a component of the Nogo-66 receptor complex. It binds NgR1 and p75 and is an additional functional componenet of the NgR1/p75 signaling complex.


Mandai,K.,, Neuron 63 (5), 614-627 (2009)Homma,S.,, Gene Expr. Patterns 9 (1), 1-26 (2009)

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$ 120.00
Cat# BP3685a
Availability: In Stock
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