|Other Names||Microtubule-associated proteins 1A/1B light chain 3C, Autophagy-related protein LC3 C, Autophagy-related ubiquitin-like modifier LC3 C, MAP1 light chain 3-like protein 3, MAP1A/MAP1B light chain 3 C, MAP1A/MAP1B LC3 C, Microtubule-associated protein 1 light chain 3 gamma, MAP1LC3C|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3691a was selected from the MAP1LC3C-Y105 region of human Phospho-APG8c (MAP1LC3C)-Y105. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium.|
|Cellular Location||Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome Note=LC3-II binds to the autophagic membranes|
|Tissue Location||Most abundant in placenta, lung and ovary.|
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Provided below are standard protocols that you may find useful for product applications.
APG8c is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. APG8c is 1 of 3 orthologs of the yeast autophagosome protein Atg8.
Tanida,I., et.al, J. Biol. Chem. 279 (35), 36268-36276 (2004)He,H., et.al, J. Biol. Chem. 278 (31), 29278-29287 (2003)
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