Phospho-IRS1(Y989) Antibody Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P35568 |
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Gene ID | 3667 |
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Other Names | Insulin receptor substrate 1, IRS-1, IRS1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | IRS1 |
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Function | May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). |
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Provided below are standard protocols that you may find useful for product applications.
Background
IRS1 may mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor it binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. It activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
References
Kawakami,A., Circulation 118 (7), 731-742 (2008)Yi,Z., Anal. Chem. 77 (17), 5693-5699 (2005)
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