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Hydroxy-HIF1A-P564 Antibody Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP3707a | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
Hydroxy-HIF1A-P564 Antibody Blocking Peptide - Product info | |
| Primary Accession | Q16665 |
| Calculated MW | 92670 Da |
Hydroxy-HIF1A-P564 Antibody Blocking Peptide - Additional info | |
| Gene ID 3091 | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
Hydroxy-HIF1A-P564 Antibody Blocking Peptide - Protein Information | |
| Name HIF1A | |
| Synonyms BHLHE78, MOP1, PASD8 | |
| Function Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia | |
| Cellular Location Cytoplasm. Nucleus. Note=Cytoplasmic in normoxia, nuclear translocation in response to hypoxia Colocalizes with SUMO1 in the nucleus, under hypoxia | |
| Tissue Location Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors | |
Hydroxy-HIF1A-P564 Antibody Blocking Peptide - Related products
AM1934a: HIF1A Antibody (ascites)
AP3707a: Hydroxy-HIF1A- P564 Antibody
AP4776a: HIF1A Antibody (N-term)
AP4776b: HIF1A Antibody (C-term)
AP7759b: HIF1Alpha Antibody (C-term)
AP7759c: HIF1Alpha Antibody (Center)
RI12452: HIF1A predesign siRNA
BP3707a: Hydroxy-HIF1A-P564 Antibody Blocking Peptide
BP4776a: HIF1A Antibody (N-term) Blocking Peptide
BP4776b: HIF1A Antibody (C-term) Blocking Peptide
BP4776d: HIF1A (HyP564) Antibody Blocking Peptide
BP7759b: HIF1Alpha Antibody (C-term) Blocking Peptide
Hydroxy-HIF1A-P564 Antibody Blocking Peptide - Research Areas
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BACKGROUND
Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas.
REFERENCES
Lee, M.N., et al. J. Natl. Cancer Inst. 102(6):426-442(2010)Mayer, A., et al. Adv. Exp. Med. Biol. 662, 399-405 (2010) Brouwer, E., et al. Clin. Exp. Rheumatol. 27(6):945-951(2009)Cho, H., et al. FEBS Lett. 581(8):1542-1548(2007)Linke, S., et al. J. Biol. Chem. 279(14):14391-14397(2004)
