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Phospho-ERBB3(Y1289) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession P21860
Peptide ID 40052
Additional Information
Gene ID 2065
Other Names Receptor tyrosine-protein kinase erbB-3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, ERBB3, HER3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ERBB3
Synonyms HER3
Function Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Epithelial tissues and brain.
Research Areas
Citations (0)

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This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form.


Huang, X., et al. Cancer Res. 70(3):1204-1214(2010)Pierce, B.L., et al. Hum. Hered. 69(3):193-201(2010)Li, D., et al. World J. Biol. Psychiatry 10 (4 PT 2), 595-598 (2009) Carr, E.J., et al. BMC Med. Genet. 10, 121 (2009) Zhang, Y., et al. BMC Cell Biol. 10, 78 (2009)

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$ 80.00
Cat# BP3708a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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