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Phospho-PDGFRB-Y751 Antibody Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP3711a | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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Phospho-PDGFRB-Y751 Antibody Blocking Peptide - Product info | |
| Primary Accession | P09619 |
| Calculated MW | 123968 Da |
Phospho-PDGFRB-Y751 Antibody Blocking Peptide - Additional info | |
| Gene ID 5159 | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
Phospho-PDGFRB-Y751 Antibody Blocking Peptide - Protein Information | |
| Name PDGFRB | |
| Synonyms PDGFR, PDGFR1 | |
| Function Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor | |
| Cellular Location Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation | |
Phospho-PDGFRB-Y751 Antibody Blocking Peptide - Related products
AP3212a: Phospho-PDGRF-Y740 Antibody
AP3711a: Phospho-PDGFRB- Y751 Antibody
AP7667a: PDGFRB Antibody (N-term)
AP7667e: PDGFRB (Y751) Antibody
RI13883: PDGFRB predesign siRNA
BP3711a: Phospho-PDGFRB-Y751 Antibody Blocking Peptide
BP7667a: PDGFRB Antibody (N-term) Blocking Peptide
BP7667d: PDGFRB Antibody Blocking Peptide
BP7667e: PDGFRB (Y751) Antibody Blocking Peptide
AJ1596a: PDGF Receptor beta (PDGFRB) antibody(C-term)
Phospho-PDGFRB-Y751 Antibody Blocking Peptide - Research Areas
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BACKGROUND
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
REFERENCES
Huang, D., et al. Cancer Res. 70(3):1053-1062(2010)Wetterskog, D., et al. Mol. Cancer Res. 7(12):2031-2039(2009)Guo, X., et al. J. Biol. Chem. 284(43):29376-29382(2009)Koos, B., et al. Am. J. Pathol. 175(4):1631-1637(2009)
