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Phospho-PAX6(T373) Antibody Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P26367
Additional Information
Gene ID 5080
Other Names Paired box protein Pax-6, Aniridia type II protein, Oculorhombin, PAX6, AN2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAX6
Synonyms AN2
Function Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1- mediated gene expression (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:P63015}. [Isoform 5a]: Nucleus {ECO:0000250|UniProtKB:P63016}
Tissue Location [Isoform 1]: Expressed in lymphoblasts.
Research Areas
Citations (0)
citation

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Background

This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes.

References

Zhang, Y., et al. J. Biol. Chem. 285(4):2527-2536(2010)McGeachie, M., et al. Circulation 120(24):2448-2454(2009)Schmidt-Sidor, B., et al. Folia Neuropathol 47(4):372-382(2009)

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$ 277.78
Cat# BP3718a
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