|Other Names||Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, PDHE1-A type I, Pdha1, Pdha-1|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.|
|Cellular Location||Mitochondrion matrix|
|Tissue Location||In all tissues, but in very low amount in testis|
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Provided below are standard protocols that you may find useful for product applications.
PDHA1 is the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Kalantry, S., et al. Nature 460(7255):647-651(2009)Sansom, S.N., et al. PLoS Genet. 5 (6), E1000511 (2009) Sidhu, S., et al. Am. J. Physiol. Heart Circ. Physiol. 295 (3), H946-H952 (2008)
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