|Other Accession||P48432, NP_003097.1, P54231|
|Other Names||Transcription factor SOX-2, SOX2|
|Target/Specificity||The synthetic peptide sequence is selected from aa 242-262 of HUMAN SOX2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
Tung, C.L., et al. Biochem. Biophys. Res. Commun. 393(3):420-425(2010)
Laga, A.C., et al. Am. J. Pathol. 176(2):903-913(2010)
Gu, H.F., et al. Gend Med 6(4):555-564(2009)
Schneider, A., et al. Am. J. Med. Genet. A 149A (12), 2706-2715 (2009) :
Zhang, X., et al. Mol. Vis. 15, 2911-2918 (2009) :
Gure, A.O., et al. Proc. Natl. Acad. Sci. U.S.A. 97(8):4198-4203(2000)
Kamachi, Y., et al. Trends Genet. 16(4):182-187(2000)
Helland, R., et al. Acta Crystallogr. D Biol. Crystallogr. 55 (PT 1), 139-148 (1999) :
Yuan, H., et al. Genes Dev. 9(21):2635-2645(1995)
Stevanovic, M., et al. Mamm. Genome 5(10):640-642(1994)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.