|Other Names||Transcription factor SOX-2, SOX2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).|
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This intronless gene encodes a member of the SRY-relatedHMG-box (SOX) family of transcription factors involved in theregulation of embryonic development and in the determination ofcell fate. The product of this gene is required for stem-cellmaintenance in the central nervous system, and also regulates geneexpression in the stomach. Mutations in this gene have beenassociated with optic nerve hypoplasia and with syndromicmicrophthalmia, a severe form of structural eye malformation. Thisgene lies within an intron of another gene called SOX2 overlappingtranscript (SOX2OT).
Gen, Y., et al. Cancer Genet. Cytogenet. 202(2):82-93(2010)Ji, J., et al. Hum. Pathol. 41(10):1438-1447(2010)Fang, X., et al. OMICS 14(4):369-384(2010)Sholl, L.M., et al. Am. J. Surg. Pathol. 34(8):1193-1198(2010)Zhang, D., et al. BMC Med. Genet. 11, 116 (2010) :
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