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Phospho-mouse CASP3(S12) Antibody Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P70677
Clone Names 111026063
Additional Information
Gene ID 12367
Other Names Caspase-3, CASP-3, Apopain, Cysteine protease CPP32, CPP-32, LICE, Protein Yama, SREBP cleavage activity 1, SCA-1, Caspase-3 subunit p17, Caspase-3 subunit p12, Casp3, Cpp32
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Casp3
Synonyms Cpp32 {ECO:0000303|PubMed:8934524}
Function Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed:8934524, PubMed:16469926). Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins (PubMed:8934524, PubMed:16469926). At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:12124386). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed:30878284). Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (By similarity). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:25231987, PubMed:33725486).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:P42574}.
Tissue Location Highest expression in spleen, lung, liver, kidney and heart (PubMed:9038361). Lower expression in brain, skeletal muscle and testis (PubMed:9038361).
Research Areas
Citations (0)
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Background

This gene encodes a protein which is a member of thecysteine-aspartic acid protease (caspase) family. Sequentialactivation of caspases plays a central role in the execution-phaseof cell apoptosis. Caspases exist as inactive proenzymes whichundergo proteolytic processing at conserved aspartic residues toproduce two subunits, large and small, that dimerize to form theactive enzyme. This protein cleaves and activates caspases 6, 7 and9, and the protein itself is processed by caspases 8, 9 and 10. Itis the predominant caspase involved in the cleavage of amyloid-beta4A precursor protein, which is associated with neuronal death inAlzheimer's disease. Alternative splicing of this gene results intwo transcript variants that encode the same protein. [provided byRefSeq].

References

Srikanth, C.V., et al. Science 330(6002):390-393(2010)Li, F., et al. Cell Stem Cell 7(4):508-520(2010)Wang, L., et al. J. Neurosci. 30(39):13201-13210(2010)Gascon, E., et al. J. Neurosci. 30(37):12414-12423(2010)Bohsali, A., et al. BMC Microbiol. 10, 237 (2010) :

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$ 277.78
Cat# BP3778b
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