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Phospho-Dnmt1(S1105) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession P26358
Clone Names 71113019
Peptide ID 71113019
Additional Information
Gene ID 1786
Other Names DNA (cytosine-5)-methyltransferase 1, Dnmt1, CXXC-type zinc finger protein 9, DNA methyltransferase HsaI, DNA MTase HsaI, MHsaI, MCMT, DNMT1, AIM, CXXC9, DNMT
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DNMT1
Synonyms AIM, CXXC9, DNMT
Function Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
Cellular Location Nucleus.
Tissue Location Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1.
Research Areas
Citations (0)

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DNA (cytosine-5-)-methyltransferase 1 has a role in theestablishment and regulation of tissue-specific patterns ofmethylated cytosine residues. Aberrant methylation patterns areassociated with certain human tumors and developmentalabnormalities. Two transcript variants encoding different isoformshave been found for this gene.


Lee, C.F., et al. J. Clin. Invest. 120(8):2920-2930(2010)Lin, R.K., et al. Cancer Res. 70(14):5807-5817(2010)Hervouet, E., et al. PLoS ONE 5 (6), E11333 (2010) :Haggarty, P., et al. PLoS ONE 5 (6), E11329 (2010) :Fujii, S., et al. Digestion 82(3):179-186(2010)

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$ 80.00
Cat# BP3780a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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