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Phospho-ERBB2(T1166) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession P04626
Clone Names 111026153
Peptide ID 111026153
Additional Information
Gene ID 2064
Other Names Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD340, ERBB2, HER2, MLN19, NEU, NGL
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ERBB2
Synonyms HER2, MLN19, NEU, NGL
Function Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1 Isoform 3: Cytoplasm. Nucleus.
Tissue Location Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
Research Areas
Citations (0)

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This gene encodes a member of the epidermal growth factor(EGF) receptor family of receptor tyrosine kinases. This proteinhas no ligand binding domain of its own and therefore cannot bindgrowth factors. However, it does bind tightly to other ligand-boundEGF receptor family members to form a heterodimer, stabilizingligand binding and enhancing kinase-mediated activation ofdownstream signalling pathways, such as those involvingmitogen-activated protein kinase and phosphatidylinositol-3 kinase.Allelic variations at amino acid positions 654 and 655 of isoform a(positions 624 and 625 of isoform b) have been reported, with themost common allele, Ile654/Ile655, shown here. Amplification and/oroverexpression of this gene has been reported in numerous cancers,including breast and ovarian tumors. Alternative splicing resultsin several additional transcript variants, some encoding differentisoforms and others that have not been fully characterized.


Geradts, J., et al. Cancer Invest. 28(9):969-977(2010)Zaoui, K., et al. Proc. Natl. Acad. Sci. U.S.A. 107(43):18517-18522(2010)Oliveras, G., et al. Ann. N. Y. Acad. Sci. 1210, 86-92 (2010) :Han, J.S., et al. Anticancer Res. 30(9):3407-3412(2010)Stackievicz, R., et al. Isr. Med. Assoc. J. 12(5):290-295(2010)

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$ 80.00
Cat# BP3781g
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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