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Phospho-mouse TSC1(S387) Blocking Peptide

Synthetic peptide

     
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Primary Accession Q9EP53
Other Accession Q9Z136, NP_075025.2
Additional Information
Gene ID 64930
Other Names Hamartin, Tuberous sclerosis 1 protein homolog, Tsc1, Kiaa0243
Target/Specificity The synthetic peptide sequence is selected from aa 382-395 of MOUSE Tsc1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tsc1
Synonyms Kiaa0243
Function In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.
Research Areas
Citations (0)

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Background

In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).

References

Kladney, R.D., et al. Cancer Res. 70(21):8937-8947(2010)
Sathaliyawala, T., et al. Immunity 33(4):597-606(2010)
Scott, C.L., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 299 (4), L455-L471 (2010) :
Bartolome, A., et al. Endocrinology 151(7):3084-3094(2010)
Squarize, C.H., et al. PLoS ONE 5 (5), E10643 (2010) :

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$ 80.00
$ 99.00
Cat# BP3814a
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