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Phospho-rat TSC1(S1141) Blocking Peptide

Synthetic peptide

     
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  • CITATIONS
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Product Information
Primary Accession Q9Z136
Other Accession NP_068626.1
Additional Information
Gene ID 60445
Other Names Hamartin, Tuberous sclerosis 1 protein homolog, Tsc1
Target/Specificity The synthetic peptide sequence is selected from aa 1134-1146 of RAT Tsc1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tsc1
Function In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.
Tissue Location Highly expressed in brain, spleen and kidney, followed by liver and heart
Research Areas
Citations (0)

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Background

In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).

References

Inoue, H., et al. Biosci. Biotechnol. Biochem. 73(11):2488-2493(2009)
Di Nardo, A., et al. J. Neurosci. 29(18):5926-5937(2009)
Chen, P., et al. Exp. Mol. Pathol. 86(2):101-107(2009)
Momose, S., et al. Biochem. Biophys. Res. Commun. 356(3):693-698(2007)
Goncharova, E., et al. J. Cell Biol. 167(6):1171-1182(2004)

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$ 120.00
Cat# BP3829a
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