|Other Names||G2/mitotic-specific cyclin-B3, CCNB3, CYCB3|
|Target/Specificity||The synthetic peptide sequence is selected from aa 273-287 of HUMAN CCNB3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I.|
|Tissue Location||Testis specific. In testis, it is expressed in developing germ cells, but not in Leydig cells. Weakly or not expressed in other tissues.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chick and Drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and be required for proper spindle reorganization and restoration of the interphase nucleus. Two transcript variants encoding different isoforms have been found for this gene.
Cheng, J., et al. Science 308(5725):1149-1154(2005)
Nguyen, T.B., et al. J. Biol. Chem. 277(44):41960-41969(2002)
Hrimech, M., et al. EMBO J. 21 (14), 3918 (2002) :
Lozano, J.C., et al. Biochem. Biophys. Res. Commun. 291(2):406-413(2002)
Mouland, A.J., et al. Virology 292(2):321-330(2002)
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