Phospho-CCNB1(S35) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P14635 |
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Other Accession | NP_114172.1 |
Gene ID | 891 |
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Other Names | G2/mitotic-specific cyclin-B1, CCNB1, CCNB |
Target/Specificity | The synthetic peptide sequence is selected from aa 28-42 of HUMAN CCNB1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CCNB1 |
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Synonyms | CCNB |
Function | Essential for the control of the cell cycle at the G2/M (mitosis) transition. |
Cellular Location | Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq].
References
Kreis, N.N., et al. Oncogene 29(41):5591-5603(2010)
van Zon, W., et al. J. Cell Biol. 190(4):587-602(2010)
Harley, M.E., et al. EMBO J. 29(14):2407-2420(2010)
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
Nantajit, D., et al. PLoS ONE 5 (8), E12341 (2010) :
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