|Other Names||Synaptic vesicle membrane protein VAT-1 homolog, 1---, VAT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2).|
|Cellular Location||Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein. Note=The majority is localized in the cytoplasm and a small amount is associated with mitochondria|
|Tissue Location||Expressed in brain. Also expressed in glioblastoma cells.|
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Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. VAT1 is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins.
Mertsch, S., et al. Neuropathol. Appl. Neurobiol. 35(4):342-352(2009)Smith, T.M., et al. Genome Res. 6(11):1029-1049(1996)Harshman, K., et al. Hum. Mol. Genet. 4(8):1259-1266(1995)
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