|Other Names||GATS-like protein 3, GATSL3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with GATSL2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to GATSL3 allosterically disrupts the interaction of GATSL3- containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.|
|Cellular Location||Cytoplasm, cytosol|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Kapranov, P., et al. Genome Res. 15(7):987-997(2005)Cheng, J., et al. Science 308(5725):1149-1154(2005)Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004)
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