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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   SAC2 Antibody (N-term) Blocking Peptide   

SAC2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9Y2H2
Peptide ID 91113294
Additional Information
Gene ID 22876
Other Names Phosphatidylinositide phosphatase SAC2, 313-, Inositol polyphosphate 5-phosphatase F, Sac domain-containing inositol phosphatase 2, Sac domain-containing phosphoinositide 5-phosphatase 2, hSAC2, INPP5F, KIAA0966, SAC2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name INPP5F (HGNC:17054)
Synonyms KIAA0966, SAC2
Function Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity).
Cellular Location Membrane, clathrin-coated pit. Early endosome. Recycling endosome. Note=Also found on macropinosomes {ECO:0000250|UniProtKB:Q8CDA1}
Tissue Location Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138).
Research Areas
Citations (0)

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SAC2 is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants have been observed, but most of them are not thought to be protein-coding.


Zhu, W., et al. Circ. Res. 105(12):1240-1247(2009)Thole, J.M., et al. Plant Cell 20(2):381-395(2008)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)

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$ 80.00
Cat# BP4732a
Availability: In Stock
Bulk Size
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