|Other Names||Retinol dehydrogenase 10, RDH10|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol.|
|Cellular Location||Microsome membrane; Single- pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein|
|Tissue Location||Detected in retina, kidney, liver, small intestine, placenta, lung, heart and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
RDH10 generates all-trans retinal from all-trans retinol and may plan an important role in the photic visual cycle. All-trans retinal is isomerized to 11-cis retinal by the retinal G protein-coupled receptor (RGR; MIM 600342) when the retinal pigment epithelium (RPE) is illuminated.
Bankovic, J., et al. Lung Cancer 67(2):151-159(2010)Takahashi, Y., et al. Biochem. J. 419(1):113-122(2009)Persson, B., et al. Chem. Biol. Interact. 178 (1-3), 94-98 (2009)
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