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ADCL1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6PIU2 |
|---|
| Gene ID | 57552 |
|---|---|
| Other Names | Neutral cholesterol ester hydrolase 1, NCEH, 311-, Arylacetamide deacetylase-like 1, NCEH1, AADACL1, KIAA1363 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NCEH1 |
|---|---|
| Synonyms | AADACL1, KIAA1363 |
| Function | Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2- acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (PubMed:17052608). May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages (By similarity). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity). May contribute to cancer pathogenesis by promoting tumor cell migration (PubMed:17052608). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein. Microsome {ECO:0000250|UniProtKB:Q8BLF1} |
| Tissue Location | Expressed in monocyte-derived macrophages. Up- regulated in invasive melanoma and breast carcinoma cell lines |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ADCL1 hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. ADCL1 may be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also ADCL1 involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. ADCL1 may contribute to cancer pathogenesis by promoting tumor cell migration.
References
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Okazaki, H., et al. J. Biol. Chem. 283(48):33357-33364(2008)Chiang, K.P., et al. Chem. Biol. 13(10):1041-1050(2006)
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