|Other Names||Neutral cholesterol ester hydrolase 1, NCEH, 311-, Arylacetamide deacetylase-like 1, NCEH1, AADACL1, KIAA1363|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration.|
|Cellular Location||Membrane; Single-pass type II membrane protein. Microsome|
|Tissue Location||Expressed in monocyte-derived macrophages. Up- regulated in invasive melanoma and breast carcinoma cell lines|
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Provided below are standard protocols that you may find useful for product applications.
ADCL1 hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. ADCL1 may be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also ADCL1 involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. ADCL1 may contribute to cancer pathogenesis by promoting tumor cell migration.
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Okazaki, H., et al. J. Biol. Chem. 283(48):33357-33364(2008)Chiang, K.P., et al. Chem. Biol. 13(10):1041-1050(2006)
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