|Other Names||Cellular nucleic acid-binding protein, CNBP, Zinc finger protein 9, CNBP, RNF163, ZNF9|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.|
|Cellular Location||Cytoplasm. Endoplasmic reticulum|
|Tissue Location||Present in all tissues examined.|
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ZNF9 encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2.
Lucchiari, S., et al. J. Neurol. Sci. 275 (1-2), 159-163 (2008) Auvinen, S., et al. Arthritis Rheum. 58(11):3627-3631(2008)Gerbasi, V.R., et al. Mol. Cell Proteomics 6(6):1049-1058(2007)Toth, C., et al. Muscle Nerve 35(2):259-264(2007)
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