|Other Names||Cyclin-dependent kinase 2-associated protein 1, CDK2-associated protein 1, Deleted in oral cancer 1, DOC-1, Putative oral cancer suppressor, CDK2AP1, CDKAP1, DOC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||specific inhibitor of the cell-cycle kinase CDK2.|
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Provided below are standard protocols that you may find useful for product applications.
CDK2AP1 is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes.
Davidsson, J., et al. Hum. Mol. Genet. 18(21):4054-4065(2009)Zolochevska, O., et al. Prostate 69(14):1586-1597(2009)Hiyoshi, Y., et al. Oncol. Rep. 22(1):35-39(2009)
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