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CRNKL1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BZJ0 |
|---|
| Gene ID | 51340 |
|---|---|
| Other Names | Crooked neck-like protein 1, Crooked neck homolog, hCrn, CRNKL1, CRN |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CRNKL1 |
|---|---|
| Synonyms | CRN |
| Function | Involved in pre-mRNA splicing process (PubMed:11991638, PubMed:12084575, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). |
| Cellular Location | Nucleus. Nucleus speckle. Note=Colocalizes with core spliceosomal snRNP proteins (PubMed:12084575). |
| Tissue Location | Widely expressed (PubMed:11342225). Highly expressed in testis (PubMed:12084575). Not detected in brain and lung (PubMed:12084575). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
CRNKL1 is essential for embryogenesis and is thought to be involved in cell cycle progression and pre-mRNA splicing. This gene is similar in sequence to crn and encodes a protein which can localize to pre-mRNA splicing complexes in the nucleus. The encoded protein, which contains many tetratricopeptide repeats, is required for pre-mRNA splicing.
References
Rame, J.E., et al. Hypertension 49(4):857-864(2007)Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) Chung, S., et al. Biochim. Biophys. Acta 1576(3):287-297(2002)Jurica, M.S., et al. RNA 8(4):426-439(2002)
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