|Other Names||Crooked neck-like protein 1, Crooked neck homolog, hCrn, CRNKL1, CRN|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pre-mRNA splicing process.|
|Cellular Location||Nucleus. Nucleus speckle. Note=Colocalizes with core spliceosomal snRNP proteins (PubMed:12084575)|
|Tissue Location||Widely expressed (PubMed:11342225). Highly expressed in testis (PubMed:12084575). Not detected in brain and lung (PubMed:12084575).|
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Provided below are standard protocols that you may find useful for product applications.
CRNKL1 is essential for embryogenesis and is thought to be involved in cell cycle progression and pre-mRNA splicing. This gene is similar in sequence to crn and encodes a protein which can localize to pre-mRNA splicing complexes in the nucleus. The encoded protein, which contains many tetratricopeptide repeats, is required for pre-mRNA splicing.
Rame, J.E., et al. Hypertension 49(4):857-864(2007)Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) Chung, S., et al. Biochim. Biophys. Acta 1576(3):287-297(2002)Jurica, M.S., et al. RNA 8(4):426-439(2002)
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